Difference: RadiobiologicalCalculations (2 vs. 3)

Revision 32019-04-18 - SusannaGuatelli

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META TOPICPARENT name="G4MSBG"
Authors: Giada Petringa Giuseppe Antonio Pablo Cirrone, Luciano Pandola,
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Short description: This test calculates the main radiobiological quantities of interest in a clinical condition: Relative Biological Effectiveness, Linear Energy Transfer and Dose. The simulated geometry reproduces the CATANA facility. The RBE is compared with the clonogenic assay performed on the U87 cell line. The dose calculation is compared with the dose distribution measured by using a Markus chamber (mod 3002).
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Short description: This test calculates the main radiobiological quantities of interest in a clinical condition: Relative Biological Effectiveness, Linear Energy Transfer and Dose. The simulated geometry reproduces the CATANA facility. The RBE is compared with the clonogenic assay performed on the U87 cell line. The dose calculation is compared with the dose distribution measured by using a Markus chamber (mod 3002).
  Reference publication:
  • Cirrone G.A.P., Cuttone G. et al., Clinical and Research Activities at the CATANA Facility of INFN-LNS: From the Conventional Hadrontherapy to the Laser-Driven Approach, Frontiers in Oncology, 10, (2017)
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  • Romano F., A Monte Carlo study for the calculation of the average linear energy transfer (LET) distributions for a clinical proton beam line and a radiobiological carbon ion beam line, Physics in Medicine and Biology 59(12):2863 (2014)
  • Chaudhary P., Marshall T.I. et al., Relative Biological Effectiveness Variation Along Monoenergetic and Modulated Bragg Peaks of a 62-MeV Therapeutic Proton Beam: A Preclinical Assessment, International Journal Radiation Oncology Biology Physics, 90(1), 27-35 (2014)
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Geant4 code: hadrontherapy
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Geant4 code: Advanced Example hadrontherapy
 
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Geant-val layout:
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Geant-val layout: LowEProtonRBE
  Reference data:
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  • U87_Pristine_P1.txt it contains the survival curve for U87 cells irradiated at the entrance position (P1) of a clinic proton spread out Bragg peak

Tested EM physics constructors:

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G4EmStandardPhysics _option4
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G4EmStandardPhysics _option4
  Tested Hadronic physics:
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QGSP_BIC_HP
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QGSP_BIC_HP
 

Description of the analysis script

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  • The script then plots the experimental Survival curve (with a confidential bar representing the maximum and minimum expected values calculated on the basis of the errors on Alphas and Betas) and the Survival curve calculated with Geant4. An example of comparison plot is shown below.

Figure_1_(1).png

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Example of output hadrontherapy-radiobiology

-- SusannaGuatelli - 2019-04-18

 
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-- GiuseppeCirrone - 2018-12-17
  • Example of output hadrontherapy-radiobiology:
 
META FILEATTACHMENT attachment="Figure_1_(1).png" attr="" comment="Example of output from hadrontherapy-radiobiology" date="1545145769" name="Figure_1_(1).png" path="Figure_1_(1).png" size="34343" user="cirrone" version="1"
 
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